Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning
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منابع مشابه
Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning
BACKGROUND Busulfan (Bu) and cyclophosphamide (Cy) are frequently included in conditioning regimens before hematopoietic stem cell transplantation (HSCT). Both drugs are detoxified by glutathione transferases (GST), and GST gene variants may explain some of the interindividual variability in pharmacokinetics and drug toxicity. METHODS The study investigated adult patients (n = 114) receiving ...
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ژورنال
عنوان ژورنال: Therapeutic Drug Monitoring
سال: 2015
ISSN: 0163-4356
DOI: 10.1097/ftd.0000000000000180